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Comparative Study
. 1984 Jun;14(3):383-90.
doi: 10.1016/0262-1746(84)90121-5.

Indomethacin enhances histamine-stimulated acid production in rabbit isolated fundic glands

E H Schwartzel Jr, R A Levine, S E Schwartz, C E Ganley
Comparative Study

Indomethacin enhances histamine-stimulated acid production in rabbit isolated fundic glands

E H Schwartzel Jr et al. Prostaglandins Leukot Med. 1984 Jun.

Abstract

The effects of 10(-4)M indomethacin on tissue prostaglandin E2 levels, cyclic AMP concentrations, and acid secretion as measured by the intraglandular accumulation of [14C]aminopyrine were evaluated in unstimulated and histamine-stimulated isolated rabbit fundic glands. Indomethacin (10(-4)M) reduced endogenous prostaglandin E2 content by 52% in unstimulated glands. Indomethacin tripled histamine (10(-6)-10(-4)M-stimulated aminopyrine uptake while not affecting aminopyrine accumulation in unstimulated glands. Indomethacin did not affect cyclic AMP levels in either the unstimulated or stimulated condition.

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