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. 1984;67(3):309-12.
doi: 10.1007/BF00291359.

The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man

O Myklebost, S Rogne, B Olaisen, T Gedde-Dahl Jr, H Prydz

The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man

O Myklebost et al. Hum Genet. 1984.

Abstract

We have demonstrated close linkage between the genes for apolipoprotein E (apoE) and apolipoprotein CII (apoCII). Families segregating for apoE protein variants were screened for a DNA restriction fragment length polymorphism close to the apoCII gene by using an apoCII cDNA clone. The maximum lod score is 4.52 (sexes combined) at a recombination frequency of zero. Given linkage, it may be assumed that no recombinations have happened in altogether 33 observed meioses. It is therefore evident that the apoCII gene is situated on chromosome 19, close to the apoE gene.

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