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. 1984 Aug 1;160(2):612-7.
doi: 10.1084/jem.160.2.612.

Expression of Tac antigen on activated normal human B cells

M Tsudo, T Uchiyama, H Uchino

Expression of Tac antigen on activated normal human B cells

M Tsudo et al. J Exp Med. .

Abstract

Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.

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References

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