Comparative Study
doi: 10.1038/310650a0.
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse
- PMID: 6088985
- DOI: 10.1038/310650a0
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Comparative Study
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse
Nature.
1984 Aug.
Abstract
The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.
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