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. 1984 Sep 21;225(4668):1320-6.
doi: 10.1126/science.6089346.

DNA markers for nervous system diseases

J F Gusella, R E Tanzi, M A Anderson, W Hobbs, K Gibbons, R Raschtchian, T C Gilliam, M R Wallace, N S Wexler, P M Conneally

DNA markers for nervous system diseases

J F Gusella et al. Science. .

Abstract

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.

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