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. 1984 Oct 5;226(4670):57-61.
doi: 10.1126/science.6089350.

Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene

T H Lee, J E Coligan, J G Sodroski, W A Haseltine, S Z Salahuddin, F Wong-Staal, R C Gallo, M Essex

Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene

T H Lee et al. Science. .

Abstract

Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.

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