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Clinical Trial
. 1984 May-Jun;31(3):124-9.

Plasma beta-endorphin levels in oral surgery patients following diazepam, fentanyl or placebo

K M Hargreaves
Clinical Trial

Plasma beta-endorphin levels in oral surgery patients following diazepam, fentanyl or placebo

K M Hargreaves. Anesth Prog. 1984 May-Jun.

Abstract

Plasma beta-endorphin, pain and anxiety were measured in patients before, during, and 1 and 3 hours following oral surgery. Diazepam and fentanyl blocked the stress induced increase in plasma beta-endorphin experienced by patients administered placebo. Moreover, intra-operative anxiety and post-operative pain appear to constitute independent and possibly equipotent stimuli for release of pituitary beta-endorphin in humans.

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References

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