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. 1984 Oct;311(5987):626-31.
doi: 10.1038/311626a0.

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

W J Leonard, J M Depper, G R Crabtree, S Rudikoff, J Pumphrey, R J Robb, M Krönke, P B Svetlik, N J Peffer, T A Waldmann, et al.

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

W J Leonard et al. Nature. 1984 Oct.

Abstract

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.

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