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. 1984 Sep;81(18):5792-6.
doi: 10.1073/pnas.81.18.5792.

Processing of complex heteroduplexes in Escherichia coli and Cos-1 monkey cells

J P Abastado, B Cami, T H Dinh, J Igolen, P Kourilsky

Processing of complex heteroduplexes in Escherichia coli and Cos-1 monkey cells

J P Abastado et al. Proc Natl Acad Sci U S A. 1984 Sep.

Abstract

Upon transformation into Escherichia coli or Cos-1 monkey cells, heteroduplex DNA made of two sequences containing many nucleotide mismatches yields a wide array of different molecules, some with a patchwork structure. Thus, complex heteroduplexes can be processed to generate many genetic variants.

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