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. 1984 Nov 6;802(1):151-4.
doi: 10.1016/0304-4165(84)90046-1.

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

J K Heath, S J Atkinson, M C Meikle, J J Reynolds

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

J K Heath et al. Biochim Biophys Acta. .

Abstract

Bone cells isolated from mouse calvariae by a sequential digestion procedure have many osteoblast characteristics: they respond to PTH and prostaglandin E2 by activation of adenylate cyclase but not to calcitonin, they stain for alkaline phosphatase and they make only type I collagen. In confluent monolayer culture, they do not secrete collagenase in appreciable quantities, unless stimulated with resorptive substances such as PTH, prostaglandin E2, 1,25(OH)2 vitamin D-3 and monocyte-conditioned medium. This suggests they play a direct role in bone resorption.

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