Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Sep;3(9):2191-6.
doi: 10.1002/j.1460-2075.1984.tb02113.x.

Hepatitis B virus transcription in the infected liver

R Cattaneo, H Will, H Schaller

Hepatitis B virus transcription in the infected liver

R Cattaneo et al. EMBO J. 1984 Sep.

Abstract

Hepatitis B virus (HBV) transcription was studied in the liver of an infected chimpanzee and compared with HBV transcription in heterologous systems. Besides the well characterized 2.3-kb surface antigen mRNA produced in most systems, a second major transcript was identified in the liver. This 3.8-kb transcript (+/- 300 bases) is slightly larger than the HBV genome and is probably involved both in core/e antigen synthesis and in HBV replication via reverse transcription. In addition, minor variants of the 2.3-kb surface antigen mRNA were characterized as probably being involved in the expression of HBsAg-related minor proteins. Finally, several potential transcription signals, identified on the HBV genome using heterologous expression systems, were found to be poorly active if at all in the infected liver, thereby stressing the importance of HBV transcription studies performed with liver material.

PubMed Disclaimer

References

    1. EMBO J. 1983;2(1):21-5 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4597-601 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1274-8 - PubMed
    1. Nucleic Acids Res. 1979 Nov 10;7(5):1175-93 - PubMed

Publication types