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. 1984 Sep:14 Suppl B:117-23.
doi: 10.1093/jac/14.suppl_b.117.

Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis

P Peretti, L Sueri, M Tosi, R Ciammarughi, G P Cadeo, B Milanesi

Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis

P Peretti et al. J Antimicrob Chemother. 1984 Sep.

Abstract

Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum.

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