Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1984 Nov;160(2):586-90.
doi: 10.1128/jb.160.2.586-590.1984.

DNA adenine methylation of GATC sequences appeared recently in the Escherichia coli lineage

T Barbeyron, K Kean, P Forterre
Comparative Study

DNA adenine methylation of GATC sequences appeared recently in the Escherichia coli lineage

T Barbeyron et al. J Bacteriol. 1984 Nov.

Abstract

We have examined the presence of methylated adenine at GATC sequences (Dam phenotype) in the DNA of 23 eubacteria and 13 archaebacteria by using isoshizomer restriction enzymes. We have found a completely Dam+ phenotype in bacteria of nine genera related to the families Enterobacteriaceae, Parvobacteriaceae, and Vibrionaceae, and in the five cyanobacteria tested. We have found a partial Dam+ phenotype in the two archaebacteria Halobacterium saccharovorum and Methanobacterium sp. strain Ivanov. All of the other archaebacteria (three genera) and eubacteria (nine genera) tested were Dam-. Phylogenetic analysis, based on the evolutionary tree of Fox et al. (Science 209:457-463, 1980), indicates that dam methylation in the Escherichia coli lineage appeared recently in bacterial evolution and is restricted to a small range of closely related bacteria.

PubMed Disclaimer

References

    1. Science. 1980 Jul 25;209(4455):457-63 - PubMed
    1. Nucleic Acids Res. 1978 Jul;5(7):2373-80 - PubMed
    1. J Mol Biol. 1977 Jul;114(1):153-68 - PubMed
    1. J Bacteriol. 1981 Jul;147(1):259-61 - PubMed
    1. Nature. 1968 Jun 15;218(5146):1066-7 - PubMed

Publication types

LinkOut - more resources