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Comparative Study
. 1984 Fall;4(4):635-43.
doi: 10.1089/jir.1984.4.635.

Isolation and bacterial expression of a murine alpha leukocyte interferon gene

B Daugherty, D Martin-Zanca, B Kelder, K Collier, T C Seamans, K Hotta, S Pestka
Comparative Study

Isolation and bacterial expression of a murine alpha leukocyte interferon gene

B Daugherty et al. J Interferon Res. 1984 Fall.

Abstract

A murine alpha interferon gene (MuIFN-alpha A) was isolated from a murine genomic DNA library in phage lambda. The gene was cloned and its sequence determined. It was expressed in Escherichia coli under the control of the trp promoter/operator which resulted in antiviral activity on mouse L-cells. MuIFN-alpha A exhibits 60% homology to HuIFN-alpha A at the amino acid level.

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