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. 1984 Jul;4(7):1372-83.
doi: 10.1128/mcb.4.7.1372-1383.1984.

Structure and arrangement of the beta-tubulin genes of Leishmania tropica

P L Huang, B E Roberts, D M Pratt, J R David, J S Miller

Structure and arrangement of the beta-tubulin genes of Leishmania tropica

P L Huang et al. Mol Cell Biol. 1984 Jul.

Abstract

We studied the organization and arrangement of the genes encoding beta-tubulin in the protozoan parasite Leishmania tropica and examined the structure and orientation of the beta-tubulin mRNA relative to the gene. There were found to be eight to nine beta-tubulin genes arranged in an array of direct tandem repeat units with a length of 3.8 kilobase pairs, and they were extremely homologous, if not identical, in sequence. These repeat units did not contain the alpha-tubulin genes. The transcribed sequences within the beta-tubulin genes were localized, and the orientation of the major alpha-tubulin mRNA was mapped on the gene by S1 nuclease analysis.

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