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. 1984 Nov;312(5991):242-6.
doi: 10.1038/312242a0.

Polyoma virus DNA replication requires an enhancer

J de Villiers, W Schaffner, C Tyndall, S Lupton, R Kamen

Polyoma virus DNA replication requires an enhancer

J de Villiers et al. Nature. 1984 Nov.

Abstract

Sequences which activate polyoma virus DNA replication are located within a region that also includes the transcriptional enhancer. We demonstrate a cis involvement of enhancers in DNA replication by showing that this region can be replaced by other enhancers, in a position- and orientation-independent manner, and that an immunoglobulin gene enhancer confers tissue-specific replicatory ability.

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