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. 1984;312(5993):413-8.
doi: 10.1038/312413a0.

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex

P van den Elsen, B A Shepley, J Borst, J E Coligan, A F Markham, S Orkin, C Terhorst

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex

P van den Elsen et al. Nature. 1984.

Abstract

The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.

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