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. 1984 Dec;312(5995):604-8.
doi: 10.1038/312604a0.

Recombinant antibodies possessing novel effector functions

M S Neuberger, G T Williams, R O Fox

Recombinant antibodies possessing novel effector functions

M S Neuberger et al. Nature. 1984 Dec.

Abstract

The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.

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