Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jul;9(7):903-15.
doi: 10.1007/BF00964522.

Functional characteristics of L-glutamate, N-methyl-D-aspartate and kainate receptors in isolated brain synaptic membranes

H H Chang, E K Michaelis, S Roy

Functional characteristics of L-glutamate, N-methyl-D-aspartate and kainate receptors in isolated brain synaptic membranes

H H Chang et al. Neurochem Res. 1984 Jul.

Abstract

L-Glutamic acid (L-Glu) and other excitatory amino acids and amino acid analogs enhanced [35S]thiocyanate (SCN-) uptake in isolated-resealed synaptic membrane vesicles. The SCN- uptake was used as a measure of membrane depolarization to evaluate the characteristics of functional excitatory amino acid receptors in the synaptic membranes. N-Methyl-D-aspartate (NMDA) and L-Glu produced additive effects on SCN- accumulation indicating the presence of distinct L-Glu and NMDA receptors. On the other hand, kainic acid (KA) and L-Glu shared either common receptor sites or ion channels. The effects of antagonists on NMDA, L-Glu, and KA stimulation of SCN- influx were consistent with previously reported electrophysiologic observations in intact neurons.

PubMed Disclaimer

References

    1. Annu Rev Pharmacol Toxicol. 1981;21:165-204 - PubMed
    1. J Physiol. 1977 Dec;273(2):367-88 - PubMed
    1. Neurochem Res. 1980 Jun;5(6):591-604 - PubMed
    1. J Physiol. 1982 Aug;329:297-317 - PubMed
    1. J Neurosci. 1981 Jun;1(6):620-5 - PubMed

Publication types