Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;68(4):286-9.
doi: 10.1007/BF00292585.

The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene

S C Wallis, J A Donald, L A Forrest, R Williamson, S E Humphries

The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene

S C Wallis et al. Hum Genet. 1984.

Abstract

We report the isolation of a genomic clone containing the apolipoprotein CII (apo CII) gene and 5' and 3' flanking sequences. A detailed restriction map of the gene has been constructed and DNA fragments that are unique, or low copy number sequences in the genome have been identified. One of these detects a common restriction fragment length polymorphism (RFLP) with the enzyme BglI. Marked linkage disequilibrium is observed between this RFLP and that detected with the apo CII cDNA clone, even though the two variable restriction enzyme sites are approximately 12kb apart. However, the usefulness of the apo CII gene as a marker for linkage studies is increased by the use of both RFLPs.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1980 May;32(3):314-31 - PubMed
    1. Biochem Biophys Res Commun. 1970 Oct 9;41(1):57-62 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jan;80(2):467-71 - PubMed
    1. Nucleic Acids Res. 1981 Jul 10;9(13):2989-98 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 May;81(10):2945-9 - PubMed

Publication types

LinkOut - more resources