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. 1984 Oct 12;51(2):165-70.
doi: 10.1016/0304-3940(84)90545-7.

Depolarization-induced increases in intracellular free calcium detected in single cultured neuronal cells

T M Perney, R J Dinerstein, R J Miller

Depolarization-induced increases in intracellular free calcium detected in single cultured neuronal cells

T M Perney et al. Neurosci Lett. .

Abstract

Microspectrofluorometry was used to examine intracellular free calcium changes in single NG108-15 neurons loaded with the Ca2+ sensitive probe, quin2. The changes in intracellular free Ca2+ were induced either by depolarizing cells with high K+ or veratridine or by the addition of ionomycin. Ca2+-free medium and various inorganic and organic calcium-channel blocking agents blocked changes in intracellular free Ca2+ levels, indicating that Ca2+ entry is most likely through voltage-sensitive calcium channels.

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