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. 1984 Dec 11;12(23):9209-26.
doi: 10.1093/nar/12.23.9209.

Optimizing selection of restriction enzymes in the search for DNA variants

E M Wijsman
Free PMC article

Optimizing selection of restriction enzymes in the search for DNA variants

E M Wijsman. Nucleic Acids Res. .
Free PMC article

Abstract

A model is developed for predicting the relative efficiencies of different enzymes for detecting DNA variants when such variants are the result of single base-pair changes. 71 enzymes are analyzed for this ability in human DNA. Their relative ranked efficiencies are influenced by the sizes of the probes used, and the size of the smallest detectable fragment produced.

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