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. 1984 Dec 1;224(2):461-6.
doi: 10.1042/bj2240461.

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

J Saklatvala, L M Pilsworth, S J Sarsfield, J Gavrilovic, J K Heath

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

J Saklatvala et al. Biochem J. .

Abstract

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

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References

    1. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1225-31 - PubMed
    1. J Clin Invest. 1979 Nov;64(5):1386-92 - PubMed
    1. Biochem J. 1979 Oct 15;184(1):177-80 - PubMed
    1. J Immunol. 1980 May;124(5):2498-501 - PubMed
    1. J Reticuloendothel Soc. 1980 Jun;27(6):621-9 - PubMed

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