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. 1984 Dec 14;125(2):797-802.
doi: 10.1016/0006-291x(84)90609-0.

Cloning of genomic DNA for human atrial natriuretic factor

M Maki, M Parmentier, T Inagami

Cloning of genomic DNA for human atrial natriuretic factor

M Maki et al. Biochem Biophys Res Commun. .

Abstract

A human genomic DNA clone for atrial natriuretic factor (ANF) gene was isolated from a human gene library using the previously cloned cDNA for rat ANF as a probe. Partial nucleotide sequencing of the cloned DNA revealed the location of a 120-bp long intron between Lys-41 and Asn-42 of the ANF precursor. Restriction mapping also suggested the existence of at least one other intron in or proximal to the 3' -untranslated region.

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