Food dye, erythrosin B, inhibits ATP-dependent calcium ion transport by brain microsomes
- PMID: 6098274
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Food dye, erythrosin B, inhibits ATP-dependent calcium ion transport by brain microsomes
Biochem Int.
1984 Nov.
Abstract
The widely-used food dye Erythrosin B inhibited ATP-dependent Ca2+ accumulation by rat brain microsomes, half-maximal inhibition requiring 1 microM dye. Addition of 0.5-20 microM dye to microsomes preloaded with Ca2+ did not cause any net Ca2+ release. 10 microM dye produced a constant inhibition of Ca2+ accumulation as the intravesicular free Ca2+ was lowered suggesting that, at low concentrations, it acts on the uptake system only. Ca2+ accumulation was ten-fold more sensitive to the dye than Erythrosin B-induced neurotransmitter release reported by others. Higher dye concentrations (100 microM) caused Ca2+ release.
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