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Comparative Study
. 1984 Dec;5(1-3):277-8.
doi: 10.1016/0143-4179(84)90081-7.

ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans

M J Kreek, J Ragunath, S Plevy, D Hamer, B Schneider, N Hartman
Comparative Study

ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans

M J Kreek et al. Neuropeptides. 1984 Dec.

Abstract

Normal responses to metyrapone were observed in most steady-state methadone maintained treatment patients. These preliminary studies suggest that in recently detoxified methadone maintained treatment patients, there may be an exaggerated response of the hypothalamic-pituitary-adrenal axis to metyrapone.

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