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Comparative Study
. 1984 Nov-Dec;5(6):1061-5.
doi: 10.1016/0196-9781(84)90171-2.

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

H Goldman, R F Berman
Comparative Study

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

H Goldman et al. Peptides. 1984 Nov-Dec.

Abstract

A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy--the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

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