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. 1984 Dec;15(5-6):664-7.
doi: 10.1007/BF01966789.

Carbon tetrachloride activation by highly purified liver mitochondrial preparations

C R de Castro, A S Bernacchi, M C Villarruel, G Fernández, J A Castro

Carbon tetrachloride activation by highly purified liver mitochondrial preparations

C R de Castro et al. Agents Actions. 1984 Dec.

Abstract

Highly purified rat liver mitochondrial preparations were found to be able to activate CCl4 to reactive metabolites that bind covalently to lipids. Part of the process is of an enzymatic nature, but most of it is non-enzymatic. The enzymatic mitochondrial CCl4 activation operates more efficiently under anaerobic conditions; it requires NADPH, is CO sensitive, is inducible by phenobarbital pretreatment and is only weakly inhibited by high concentrations of cyanide or azide. The non-enzymatic mitochondrial CCl4 activation is not inhibited by CO and proceeds equally well under air or nitrogen.

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References

    1. Br J Exp Pathol. 1980 Oct;61(5):505-11 - PubMed
    1. FEBS Lett. 1978 Jan 1;85(1):35-9 - PubMed
    1. Xenobiotica. 1973 Jan;3(1):1-11 - PubMed
    1. J Biol Chem. 1962 Feb;237:587-95 - PubMed
    1. Res Commun Chem Pathol Pharmacol. 1973 Jul;6(1):175-83 - PubMed

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