Effects of histamine and H1 and H2-receptor antagonists on the wet-dog-shaking episodes in rats induced with lithium chloride

Abstract

In the experiments carried out on Wistar rats it was demonstrated that histamine administered intraventricularly had no effect on the number of wet-dog-shaking episodes induced with lithium chloride. Thenalidine and antazoline, antagonists of the H1 receptor, and cimetidine and ranitidine, antagonists of the H2 receptor reduced the number of shaking episodes proportionally to the dose. These results may suggest that the reduction of the number of shaking episodes induced with lithium chloride was connected with blockade of histamine receptors, although an indirect effect of H1 and H2-receptor antagonists on the serotoninergic and cholinergic systems cannot be ruled out.