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. 1983 Dec;80(4):711-7.
doi: 10.1111/j.1476-5381.1983.tb10062.x.

Beta-adrenoceptors of the human myocardium: determination of beta 1 and beta 2 subtypes by radioligand binding

A Heitz, J Schwartz, J Velly

Beta-adrenoceptors of the human myocardium: determination of beta 1 and beta 2 subtypes by radioligand binding

A Heitz et al. Br J Pharmacol. 1983 Dec.

Abstract

beta-Adrenoceptors of the human myocardium were investigated with binding studies using 125iodocyanopindolol (ICYP) as ligand. Inhibition of ICYP-binding by betaxolol (a selective beta 1-antagonist) and ICI 118551 (a selective beta 2-blocking drug) resulted in non-linear Scatchard-plots suggesting that both beta-adrenoceptor subtypes are present in human left atrium and left ventricle. Computer analysis of the data gave a beta 1/beta 2-adrenoceptor ratio of approximately 65:35 both for left atrium and for left ventricle.

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