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Clinical Trial
. 1980 Feb 16;1(8164):336-8.
doi: 10.1016/s0140-6736(80)90885-5.

Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis

W Weimar, R A Heijtink, F J ten Kate, S W Schalm, N Masurel, H Schellekens, K Cantell
Clinical Trial

Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis

W Weimar et al. Lancet. .

Abstract

In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12 x 10(6) reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.

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