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Clinical Trial
. 1980 Feb 16;1(8164):339-40.
doi: 10.1016/s0140-6736(80)90886-7.

Possible prevention of neural-tube defects by periconceptional vitamin supplementation

R W Smithells, S Sheppard, C J Schorah, M J Seller, N C Nevin, R Harris, A P Read, D W Fielding
Clinical Trial

Possible prevention of neural-tube defects by periconceptional vitamin supplementation

R W Smithells et al. Lancet. .

Abstract

Women who had previously given birth to one or more infants with a neural-tube defect (NTD) were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants/fetuses of fully supplemented mothers (0.6%) had an NTD, compared with 13 of 260 infants/fetuses of unsupplemented mothers (5.0%).

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