Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1980 Feb;68(2):196-8.
doi: 10.1111/j.1476-5381.1980.tb10407.x.

A comparison of the bronchoconstrictor and beta-adrenoceptor blocking activity of propranolol and acebutolol

J MacLagan, U M Ney
Comparative Study

A comparison of the bronchoconstrictor and beta-adrenoceptor blocking activity of propranolol and acebutolol

J MacLagan et al. Br J Pharmacol. 1980 Feb.

Abstract

The bronchoconstrictor and beta-adrenoceptor blocking activity of (+/-)-propranolol, acebutolol and two of its analogues were compared in a group of littermate rats. Whilst the analogues of acebutolol had similar bronchoconstrictor potency to propranolol, acebutolol had considerably less activity. No correlation could be found between the degree of bronchoconstriction produced by the four drugs and their beta-adrenoceptor blocking activity in the airway smooth muscle. Acebutolol and its analogues show a wide properties could be related to the production of bronchospasm.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Br J Pharmacol Chemother. 1966 Feb;26(2):322-33 - PubMed
    1. Br J Anaesth. 1967 Dec;39(12):919-26 - PubMed
    1. Thorax. 1969 Sep;24(5):616-8 - PubMed
    1. J Appl Physiol. 1973 May;34(5):624-7 - PubMed
    1. J Med Chem. 1976 Mar;19(3):399-402 - PubMed

Publication types

LinkOut - more resources