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Clinical Trial
. 1980 Feb 9;280(6211):360-1.
doi: 10.1136/bmj.280.6211.360.

Ketotifen in adult asthma

A J Dyson, A D Mackay
Clinical Trial

Ketotifen in adult asthma

A J Dyson et al. Br Med J. .

Abstract

The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.

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