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. 1976 Aug 1;157(2):521-4.
doi: 10.1042/bj1570521.

Absence of binding of pancreatic and urinary kallikreins to alpha 2-macroglobulin

E Vahtera, U Hamberg

Absence of binding of pancreatic and urinary kallikreins to alpha 2-macroglobulin

E Vahtera et al. Biochem J. .

Abstract

Pancreatic and urinary kallikreins failed to form the typical serine proteinase complex with alpha2M (alpha2-macroglobulin). Studies were performed to compare this with the binding of trypsin to alpha2M at various molar binding ratios, with the use of Sephadex G-200 gel filtration to separate free and alpha2M-bound enzyme fractions. The subunit conversion was totally absent with pancreatic kallikrein from lhich traces of a binding proteinase had been removed. The lack of binding is believed to be the result of the restricted specificity of the kallikreins.

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