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. 1980 Apr 5;1(8171):738-40.
doi: 10.1016/s0140-6736(80)91234-9.

Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins

B A McVerry, C Fisher, A Hopp, E R Huehns

Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins

B A McVerry et al. Lancet. .

Abstract

Plasma proteins glucosylated in vitro were injected repeatedly into 7 mice. A group of 4 was given multiple injections of non-glucosylated plasma proteins and another 10 were untreated. 5 of 7 mice given glucosylated proteins had glomerular-basement-membrane thickening on electron microscopical examination. This feature is characteristic of human and experimental diabetic renal disease. These results suggest that there may be a link between plasma-protein glucosylation and diabetic nephropathy.

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