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. 1980 May 10;1(8176):987-9.
doi: 10.1016/s0140-6736(80)91434-8.

Effect of neurotensin on gastric function in man

A M Blackburn, D R Fletcher, S R Bloom, N D Christofides, R G Long, M L Fitzpatrick, J H Baron

Effect of neurotensin on gastric function in man

A M Blackburn et al. Lancet. .

Abstract

Neurotensin is a peptide recently discovered in the human ileum and it is released into plasma after ingestion of food. Neurotensin was infused intravenously into 12 healthy volunteers at a mean dose of 2.4 pmol/kg/min, the mean rise in plasma levels being 89 +/- 8 pmol/l. An inhibition of both gastric acid and pepsin output, and also a delay in gastric emptying of oral glucose, were observed. Neurotensin may therefore have a physiological role in modulating gastric function in man.

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