doi: 10.1016/s0140-6736(80)92890-1.
Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism
- PMID: 6104265
- DOI: 10.1016/s0140-6736(80)92890-1
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Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism
Lancet.
.
Abstract
20 patients with primary biliary cirrhosis (PBC) had circulating IgG-containing immune complexes. These complexes bind to lymphocyte Fc gamma-receptors in vitro; there was also evidence for in-vivo binding. Such in-vivo binding to T and K lymphocytes may exert an immunomodulatory effect on these cells, and may also explain some of the serological and cellular abnormalities in PBC.
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