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. 1980 Jul 5;2(8184):9-13.
doi: 10.1016/s0140-6736(80)92890-1.

Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism

G P Sandilands, I Galbraith, F M Reid, P R Mills, R N MacSween

Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism

G P Sandilands et al. Lancet. .

Abstract

20 patients with primary biliary cirrhosis (PBC) had circulating IgG-containing immune complexes. These complexes bind to lymphocyte Fc gamma-receptors in vitro; there was also evidence for in-vivo binding. Such in-vivo binding to T and K lymphocytes may exert an immunomodulatory effect on these cells, and may also explain some of the serological and cellular abnormalities in PBC.

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