doi: 10.1016/s0140-6736(80)90060-4.
Remission induction with adenosine-deaminase inhibitor 2'-deoxycoformycin in Thy-lymphoblastic leukaemia
- PMID: 6105339
- DOI: 10.1016/s0140-6736(80)90060-4
Item in Clipboard
Remission induction with adenosine-deaminase inhibitor 2'-deoxycoformycin in Thy-lymphoblastic leukaemia
Lancet.
.
Abstract
Two patients with relapsed acute lymphoblastic leukaemia of thymic phenotype (Thy-ALL) resistant to all conventional chemotherapy achieved complete remission when treated with 2'-deoxycoformycin, a selectively lymphocytotoxic compound that acts by inhibition of the enzyme adenosine deaminase. These observations show that malignant thymocytes are dependent on adenosine-deaminase activity and suggest that it may be possible to use deoxycoformycin in other patients with Thy-ALL to induce remission or to kill Thy-ALL blasts in bone marrow harvested before autologous bone-marrow transplantation, leaving normal haemopoietic stem cells intact.
Similar articles
-
Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin.Adv Exp Med Biol. 1979;122B:347-50. doi: 10.1007/978-1-4684-8559-2_56. Adv Exp Med Biol. 1979. PMID: 317568 No abstract available.
-
Therapeutic selectivity of and predication of response to 2'-deoxycoformycin in acute leukaemia.Lancet. 1981 Dec 5;2(8258):1250-4. doi: 10.1016/s0140-6736(81)91491-4. Lancet. 1981. PMID: 6118669
-
Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.Proc Natl Acad Sci U S A. 1984 Jan;81(1):253-7. doi: 10.1073/pnas.81.1.253. Proc Natl Acad Sci U S A. 1984. PMID: 6607471 Free PMC article.
-
2'-Deoxycoformycin (pentostatin) for lymphoid malignancies. Rational development of an active new drug.Ann Intern Med. 1988 May;108(5):733-43. doi: 10.7326/0003-4819-108-5-733. Ann Intern Med. 1988. PMID: 3282467 Review.
-
Enzymes of purine metabolism in lymphoid neoplasms, clinical relevance for treatment with enzyme inhibitors.Klin Wochenschr. 1988 Jun 1;66(11):467-74. doi: 10.1007/BF01876167. Klin Wochenschr. 1988. PMID: 2841534 Review.
Cited by
-
Biochemical enzyme analysis in acute leukaemia.J Clin Pathol. 1985 Feb;38(2):117-27. doi: 10.1136/jcp.38.2.117. J Clin Pathol. 1985. PMID: 2981904 Free PMC article. Review.
-
Pentostatin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in lymphoproliferative disorders.Drugs. 1993 Oct;46(4):652-77. doi: 10.2165/00003495-199346040-00006. Drugs. 1993. PMID: 7506651 Review.
-
Enzyme and membrane markers in leukaemia: recent developments.J Clin Pathol. 1981 Mar;34(3):254-62. doi: 10.1136/jcp.34.3.254. J Clin Pathol. 1981. PMID: 6785321 Free PMC article. Review.
-
Purification, characterization and radioimmunoassay of adenosine deaminase from human leukaemic granulocytes.Biochem J. 1981 May 1;195(2):389-97. doi: 10.1042/bj1950389. Biochem J. 1981. PMID: 6947796 Free PMC article.
-
Purinogenic lymphocytotoxicity: clues to a wider chemotherapeutic potential for the adenosine deaminase inhibitors.Cancer Chemother Pharmacol. 1983;10(2):73-8. doi: 10.1007/BF00446213. Cancer Chemother Pharmacol. 1983. PMID: 6600985 No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
