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Case Reports
. 1980 Sep 6;2(8193):502-5.
doi: 10.1016/s0140-6736(80)91833-4.

Gene enrichment in an American Indian population: an excess of severe combined immunodeficiency disease

S Murphy, A Hayward, G Troup, E J Devor, T Coons
Case Reports

Gene enrichment in an American Indian population: an excess of severe combined immunodeficiency disease

S Murphy et al. Lancet. .

Abstract

A subgroup of Athabascan Indians in Arizona and New Mexico was found to have an unusually high incidence of severe combined immunodeficiency, probably due to founder effect. Closed genetic pressures have limited their histocompatibility-antigen heterogeneity, enabling 3 patients to be grafted, 2 of them across HLA-B locus barriers.

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