Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Aug;77(8):4489-93.
doi: 10.1073/pnas.77.8.4489.

Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus

A V Schally, W Y Huang, R C Chang, A Arimura, T W Redding, R P Millar, M W Hunkapiller, L E Hood

Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus

A V Schally et al. Proc Natl Acad Sci U S A. 1980 Aug.

Abstract

An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.

PubMed Disclaimer

References

    1. Lancet. 1977 Mar 26;1(8013):666-8 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1505-8 - PubMed
    1. FEBS Lett. 1980 Jan 1;109(1):55-8 - PubMed
    1. Biochemistry. 1978 May 30;17(11):2124-33 - PubMed
    1. Biochemistry. 1976 Feb 10;15(3):509-14 - PubMed

Publication types

LinkOut - more resources