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. 1980 Nov;21(11):996-1001.
doi: 10.1136/gut.21.11.996.

Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux

W E Thomas

Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux

W E Thomas. Gut. 1980 Nov.

Abstract

The hypersecretion of gastric acid in response to pentagastrin, caused by duodenal reflux, was tested in dogs. An infusion of 0.25 micrograms/kg/h was found to restore the raised responses seen in the reflux dogs to control levels. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and of gastrin release, but it was a weak inhibitor of histamine. These studies suggest that somatostatin may have played a part in acid homeostasis.

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