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Case Reports
. 1980 Dec;2(8208-8209):1332-4.
doi: 10.1016/s0140-6736(80)92398-3.

Fatal disseminated BCG infection in an 18-year-old boy

A Mackay, T Macleod, M J Alcorn, M Laidlaw, I M Macleod, J S Millar, B H Stack, R G White
Case Reports

Fatal disseminated BCG infection in an 18-year-old boy

A Mackay et al. Lancet. 1980 Dec.

Abstract

Death from disseminated infection with BCG (bacille Calmette-Guérin) after routine vaccination is rare, and various immune defects may be responsible. An 18-year-old boy died with widespread lymph-node, bone, lung, and liver involvement 6 years after BCG vaccination. Total numbers of B lymphocytes and T lymphocytes were normal, but T lymphocytes, while transforming normally in the presence of non-specific mitogens, did not transform in the presence of purified protein derivative. Delayed-type hypersensitivity skin tests were negative. Monocytes containing alpha-naphthylacetate esterase were absent.

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