Gamma-glutamyltransferase in Morris hepatomas 5123D passaged in Buffalo and in F1 (Buffalo x Wistar) rats

Abstract

Comparative biochemical and immunological investigations were performed on purified gamma-glutamyltransferase from the Morris hepatoma 5123D and from the 5123D/AS variant passaged in F1 (Buffalo x Wistar) rats. The enzyme was also localized in hepatoma sections by immunofluorescent technique. The obtained results confirm the hypothesis that low gamma-glutamyltransferase activity in Morris hepatoma 5123D/AS is caused by the enzymatic protein defficiency and not by the inhibition of the enzyme.