Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilization

Abstract

The efficacy of transcervical insertions of quinacrine hydrochloride pellets to produce tubal occlusion has been evaluated in a study of 139 women in Santiago, Chile. At one year, the pregnancy rate was 3.1%, an acceptable rate for a nonsurgical method of female sterilization.

PIP: 139 volunteers seeking permanent sterilization were treated with 3 transcervical insertions of quinacrine hydrochloride pellets to produce tubal occlusion. The procedure is essentially the same as inserting an IUD. Pregnancy rate at 1 year was 3.1%, and results showed this method to be more effective than the quinacrine solution method, which entails a higher risk of transient toxic psychosis.