Intubation conditions and reversibility of a new non-depolarizing neuromuscular blocking agent, Org-NC45

Abstract

We describe the clinical use, for intubation purposes, of Org-NC45, a new non-depolarizing neuromuscular blocking agent. Administration of 50 and 72 microgram/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases ws a significant change in blood pressure or heart rate seen after the injection of Org-NC45. The resulting block was of short duration and, if necessary, was easily reversed with neostigmine or pyridostigmine.