Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Nov 21;68(2):205-8.
doi: 10.1016/0014-2999(80)90324-6.

Changes in the sensitivity of smooth muscle to neurotransmitter during acute morphine treatment and its association with analgesia

S Ramaswamy, N P Pillai, V Gopalakrishnan, M N Ghosh

Changes in the sensitivity of smooth muscle to neurotransmitter during acute morphine treatment and its association with analgesia

S Ramaswamy et al. Eur J Pharmacol. .

Abstract

Acute in vivo administration of morphine to mice produced dose- and time-dependent subsensitivity to acetylcholine in ileum and supersensitivity to norepinephrine in vas deferens. These responses were specific to the agonist as potassium chloride-induced responses were not altered. A correlation was observed between the analgesia and the sensitivity changes produced by morphine. The sensitivity changes were mediated through opiate receptors as naloxone antagonised the effect of morphine.

PubMed Disclaimer

Similar articles

See all similar articles

Publication types

LinkOut - more resources