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Clinical Trial
. 1981 Apr 11;1(8224):797-800.
doi: 10.1016/s0140-6736(81)92679-9.

Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in french haemodialysis units: II, Haemodialysis patients

J Crosnier, P Jungers, A M Couroucé, A Laplanche, E Benhamou, F Degos, B Lacour, P Prunet, Y Cerisier, P Guesry
Clinical Trial

Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in french haemodialysis units: II, Haemodialysis patients

J Crosnier et al. Lancet. .

Abstract

A vaccine against hepatitis B surface antigen (Institut Pasteur Production) was assessed in 138 haemodialysis patients in a placebo-controlled randomised double-blind trial. In an interim analysis, hepatitis B infections were observed in 21% of the vaccine group and 45% of the placebo group (p less than 0.02). 2 of the infections in the vaccine group and 12 of the infections in the placebo group occurred after the third injection. 60% of the vaccine recipients had an immune response. 4 months after the first injection the mean titre of anti-HBs was 120 mlU/ml.

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