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. 1980 Jul;10(1):67-73.
doi: 10.1016/0304-3835(80)90067-1.

The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures

G S Probst, S B Neal

The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures

G S Probst et al. Cancer Lett. 1980 Jul.

Abstract

The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.

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